منابع مشابه
Adding Experimental Arms to Ongoing Clinical Trials
Multi-arm clinical trials use a single control arm to evaluate multiple experimental treatments. In most cases this feature makes multi-arm studies considerably more efficient than two-arm studies that evaluate single experimental treatments. A bottleneck for implementation is the requirement that experimental treatments need to be available at the enrollment of the first patient. New drugs are...
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AKI is an important public health issue. AKI is a common hospital complication associated with increased inhospital and long-term mortality, extensive morbidity (including prolonged hospital length of stay), and an estimated annual cost of at least $10 billion in the United States. At present, no specific therapy has been developed to prevent AKI, hasten recovery of kidney function, or abrogate...
متن کاملOngoing clinical trials in intracerebral hemorrhage.
ntracerebral hemorrhage (ICH) accounts for 10% to 15% of all strokes. ICH continues to impart a considerable degree of morbidity and mortality, with 30-day mortality ranging from 44% to 50%. ICH remains a devastating disease, and current treatment options lag far behind those for ischemic stroke. There are no approved therapies, which improve outcome, and treatment remains mainly supportive. De...
متن کاملProtecting patients in ongoing clinical trials.
In the fall of 2008, retiree John Dennis sued Anapharm, one of Canada’s largest clinical research firms, alleging he’d been injured after participating in a clinical trial three years earlier. Dennis, of Drummondville, Quebec, ingested a trial drug as part of a study in the fall of 2005 and was rushed from the testing facility to the emergency room at McGill University Health Centre in Montréal...
متن کاملOngoing Clinical Trials in Testicular Cancer: The TIGER Trial.
In France by the PHRC (le programme hospitalier de recherche clinique), in Italy by AIFA (Agenzia Italiana del Farmaco) and in the UK by CRUK (Cancer Research UK) and the Orchid Foundation. For Germany, a grant application at the Deutsche Krebshilfe (DKH) is currently under review. The trial has been designed to prospectively assess the impact of sequential high-dose chemotherapy given at first...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2010
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noq116.s9